Abstract
Objective To compare the effect of two kinds of cardioplegia on endothelial activation and inflammatory response in immature heart during cardiopulmonary bypass (CPB).Methods Fourteen piglets,randomized to histidihe-tryptophan-ketoglutarate (HTK) group (H group) and blood cardioplegia group (B group),were put on CPB.The coronary artery and ventricular tissues after CPB were assayed for the contents of endothelial nitrogen oxygen synthetic enzyme (eNOS),vascular endothelial growth factor (VEGF),inducible nitrogen oxygen synthetic enzyme (iNOS),tumor necrotic factor-α (TNF-α),interleukin-1β (IL-1β) and IL-2.Results There were no significant differences in the contents of eNOS and VEGF in coronary vessels and iNOS,TNF-α,IL-1 β and IL-2 in myocardium between H group and B group (P ＞ O.05).Conclusion Compared with blood cardioplegia,HTK solution can preserve the contents of eNOS and VEGF in coronary endothelium and Prevent the over-expression of iNOS and pro-inflammatory cytokines in myocardium. Key words: Cardioplegia; Cardiopulmonary bypass; Immature heart; Inflammatory response
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