Abstract
Objective: To study the comparative effect of NR-AG-I and NR-AG-II (polyherbal formulations) against gentamicin- induced nephrotoxicity in rats. Materials and methods: Nephroprotective activity was evaluated in gentamicin induced nephrotoxicity (80mg/kg/day s.c) in male albino rats. NR-AG-I and NR-AG-II were tested at a dose of 150mg/kg/day p.o. All the treatments were given for 12 days. Urea clearance and microscopical examinations of kidney performed after the treatment. Results: Gentamicin treatment caused nephrotoxicity as evidenced by significant decrease in urea clearance and was prevented by both formulations. Study of renal microscopy showed necrosis, epithelial loss with granular degeneration and fatty changes in gentamicin treated rats and was reversed by both formulations, but NR-AG-I proven to be better formulation in our experimental study. Conclusion: Our data suggest that treatment with NR-AG-1 and NR-AG-II may be useful in reducing gentamicin nephrotoxicity in rats.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
