Abstract
Aim & Background: To study the cytotoxic effects of Acacia concinna and compare it against Sodium hypochlorite. Materials and method: Pure methanolic extract of A.concinna was prepared using a soxhlet apparatus and concentrated with a rotary evaporator. Human PDL cell fibroblast was seeded in 96-well plates and was divided into 3 groups: Control Group, A.concinna extract & 3% Sodium Hypochlorite. All specimens were incubated for 1-hour and 24-hour intervals. After the specified time periods, the test medium was subjected to MTT assay. Results: Sodium hypochlorite showed the least cell viability at both time intervals. There was no significant difference in cell viability at 24-hour time interval with the sample and control group. Conclusion: Extract of A.concinna showed significantly greater cell viability than NaOCl. Hence this novel irrigant can be an alternative to NaOCl in terms of its biocompatibility Clinical Significance: This herbal formulation can be used as an alternative to the established hypochlorite for root canal irrigation.
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