Abstract
The minimal dose capable of producing chronic intoxication in the albino rat has been determined for sodium fluoride, sodium fluosilicate, barium fluosilicate, and sodium aluminum fluoride (natural cryolite). Male rats ranging in weight from 30 to 60 gm. were placed on a basic diet consisting of corn meal 73 gm., linseed oil cake meal 10 gm., alfalfa 2 gm., casein 10 gm., codliver oil 3 gm., bone ash 1 1/2 gm., sodium chloride 1/2 gm. For each compound studied 6 control rats were placed on this diet, and for each dosage level 6 rats were placed on the same diet to which a weighed amount of the fluorine compound had been added and evenly distributed by means of a mechanical mixer. Analyses showed even distribution of the toxic agent throughout the basic diet. For each compound a series of dosage levels was employed, each dose being one-half the preceding dose.The criterion of toxic action was bleaching of the upper and lower, especially the lower, incisor teeth. Table I summarizes the data. In the case of ...
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