Abstract
Indian cobra venom contains many phospholipase A 2 (PLA 2) toxins. In the present study two toxic PLA 2s have been purified from the Indian cobra ( Naja naja naja) venom by column chromatography. The NN-XI a-and NN-XI b-PLA 2s have mol. wts between 10,700 and 15,000. The NN-XI a-PLA 2 induces myotoxic effects, oedema and neurotoxicity in mice and has an i.p. ld 50 of 8.5 mg/kg body weight. The NN-XI a-PLA 2 is also cytotoxic to Ehrlich ascites tumour cells. The other PLA 2, NN-XI b, in contrast has an i.p. ld 50 of 0.22 mg/kg body weight, and it induces acute neurotoxicity. The NN-XI b-PLA 2 is devoid of the other biological activities which are exhibited by NN-XI a-PLA 2.
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