Comparative characteristics of treatment methods for chronic stomatitis in pediatric patients

Abstract

Study of the immunological effectiveness of the use of standard treatment, according to protocols, and the use of standard treatment in combination with magnetic laser exposure in children with chronic stomatitis. Materials and methods. 80 children with chronic stomatitis aged 4 to 18 years were examined: group E (21 children) aged 4-7 years and group R (19 children) aged 8-18 years received only standard treatment, group F (21 children) at the age of 4-7 years and group S (19 children) at the age of 8-18 years received standard treatment in combination with magnetic laser exposure. The control groups consisted of children without a history of diseases of the oral mucosa aged 4-7 years (group C, n=20) and children aged 8-18 years (group D, n=20). The levels of alpha-amylase, lysozyme, lactoperoxidase, myeloperoxidase, immunoglobulin M, and secretory immunoglobulin A were determined. Results. In group E, the initial levels of lactoferrin, sIgA, IgM and myeloperoxidase were statistically significantly higher (p<0.05) than in group C. After treatment, the levels of lactoferrin, sIgA and myeloperoxidase decreased compared to the initial level, but retained statistically significant differences in comparison with the control group (p<0.05). In group R, the initial levels of lysozyme, sIgA and myeloperoxidase were statistically significantly different (p<0.05). Lysozyme and sIgA levels were lower than in children in group D, and myeloperoxidase levels were higher. After treatment, the level of lysozyme increased relative to the initial level, but statistically significant differences were revealed in comparison with the control group (p <0.05). The level of sIgA reached the values of the control group (p>0.05). In group F, the levels of lysozyme, lactoferrin, sIgA and myeloperoxidase were statistically significantly higher (p<0.05) than in children of group C. The level of IgM was statistically significantly lower (p<0.05). After treatment, the levels of lysozyme, lactoferrin, sIgA, IgM and myeloperoxidase reached the levels of group C (p>0.05). In group S, the levels of lysozyme and lactoferrin were statistically significantly lower (p<0.05) than in children of group D, and the level of myeloperoxidase was higher (p<0.05). After treatment, the levels of lysozyme, lactoferrin and myeloperoxidase reached the levels of the control group (p>0.05). In groups E and R, positive dynamics were observed in the levels of the studied indicators, however, statistically significant differences remained (p>0.05) in comparison with control groups C and D. In group F and S, the levels of the studied indicators reached the levels of control groups C and D, and there were no statistically significant differences (p <0.05). Conclusion. The inclusion of magnetic laser exposure in standard therapy promotes the dynamics of immune status indicators (lysozyme, lactoferrin, alpha-amylase, myeloperoxidase, immunoglobulin M, secretory immunoglobulin A) in children with chronic stomatitis aged 4-18 years.