Comparative characteristics of the well-healing xerogel effect based on the neutral hydrozol of titanium dioxide for burner therapy

Abstract

Purpose of the study. In order to create the basis for prospective wound coatings the wound healing effect of xerogel based on neutral hydrosol of titanium dioxide was studied. Materials and methods. After modeling the Wistar outbred runoff in 40 male rats, the wound defect on the skin of the intertropatular region was closed with a bandage. The animals were divided into four groups: Four groups: a control group, (10 rats) in which no drugs were applied to the burn surface; 2 – the group of the comparison preparation, 10 males to whom after the modeling of the burn on the wound surface was applied daily the preparation of comparison argosulfan 3 – experimental group № 1, included 10 males to whom after the modeling of the burn on the wound surface was applied daily the xerogel, in a dose of 0.1 ml/100 g of animal body weight, 4 – experimental group № 2, included 10 males, who after modeling the pathology were daily copied on the wound surface, in a dose of 0.2 ml/100 g of animal body weight. Results. The complex of morphofunctional changes in experimental groups included changes in the epidermis – restoration of a more complete epidermal layer with skin appendages. Probably, it is provided not only by direct stimulation of cell proliferation of basal and studded layers, but also by other mechanisms, as indicated by the nuclear cytoplasmic ratio. In the connective tissue base of the wound effect of experimental groups it was noted the formation of a more extensive network of blood vessels of the hemomicrocirculatory channel and a decrease in the signs of venous hyperemia. Conclusions. Thus, the effective dose of xerogel is 2 ml/kg. The revealed complex of local morphofunctional rearrangements allows the xerogel to be used in diseases and conditions characterized by the disturbance of the skin integrity, including a burn lesion.