Comparative characteristics of the hemostatic potential in cord blood and in blood from premature and full-term newborns after birth according to the thromboelastography.

Abstract

The comparative characteristic of indicators of thromboelastography of umbilical cord blood and venous blood for 1-3 days of life at full-term and premature newborns is carried out. The study included 40 full term and 68 preterm infants at 1-5 days of life. Body weight of children was 3413.8±54.6 g and 2039.4±75.9 g, gestational age - 40.0±0.3 and 33.5±0.33 weeks, respectively. Mixed umbilical cord blood and venous blood taken from the ulnar vein of a child for 1-3 days of life were studied. The obtained data indicate that the main focus in the performance of thromboelastograms in premature and full-term newborns in the umbilical and venous blood are preserved. In preterm infants in cord blood decreased activity of the plasma level and functional activity of platelets, as well as reduced coagulation potential in General. After birth, premature newborns in the venous blood showed a slowdown in blood clotting, a decrease in the rate of formation and strength of clots. There is also a decrease in the functional activity of platelets, coagulation index and a more pronounced change in hemostatic potential in the direction of hypocoagulation. In full-term children, changes in the functional state of platelets and clot lysis in the umbilical and venous blood after birth do not change significantly. Hypercoagulable orientation of hemostasis in these children at birth was established.