Abstract
The article provides an overview of modern data on the main gel bases used in the technology of semisolid dosage forms. The main classes of gelling substances are characterized. According to data, the choice of excipient must be justified from the point of view of the physicochemical properties of the active substance, and depends on the place of application of the gel.
Highlights
Gels are semisolid dosage forms which are used for local or transdermal delivery of active ingredients, or emollient or/and protective action
This is due to differences in the physicochemical properties of the active components that make up the semisolid dosage form compositions
The most rational classification, which fully reflects the production technology of semisolid dosage form, is the classification of the bases according to the ability to interact with water
Summary
Gels are semisolid dosage forms which are used for local or transdermal delivery of active ingredients, or emollient or/and protective action. In addition to gelling agents of natural or synthetic origin, preservatives, stabilizers and emulsifiers, one or more active ingredients. Gelling agents can act as stabilizers for such dispersed systems as suspensions or emulsions. Modern pharmaceutical manufacturing uses a wide variety of semisolid dosage form bases. This is due to differences in the physicochemical properties of the active components that make up the semisolid dosage form compositions. There are several classifications of bases for semisolid dosage forms. The classification of bases for semisolid dosage form according to sources of receipt is presented in table 1
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