Comparative Characteristics of Changes in Neuron Organelles During Two-Stage Ligation of the Common Carotid Arteries in Phylogenetically Different Sections of the Brain Cortex of Outbreed White Rats

Abstract

Ultrastructural characteristics of changes in neuronal organelles during two-stage ligation of the common carotid arteries in phylogenetically different sections are important indicators of the degree of brain damage during ischemic exposure, which necessitates the study of this aspect. Two-stage subtotal cerebral ischemia was performed on 24 outbred male rats by sequential ligation of both common carotid arteries with an interval of 7 days, 3 days and 1 day. This method of modeling subtotal ischemia makes it possible to study the dynamics of the consequences of severe cerebral ischemia and the pathogenesis of ischemic brain damage. Thus, compensatory changes in neuronal organelles during two-stage ligation of the common carotid arteries included expansion of the cisternae of the Golgi complex and hyperplasia of the endoplasmic reticulum, as a reflection of the activation of compensation mechanisms during hypoxia.