COMPARATIVE CHARACTERISTIC OF MULTI-ENVIRONMENTAL CARCINOGEIC RISK FOR ADOLESCENT HEALTH

Abstract

The main aim of the work is a comparative characteristic of carcinogenic risk for the health of the adolescent and adult population from exposure to chemical contaminants on multi-environmental ingestion of chemical substances (drinking water, soil, atmospheric air, foods). A high level of total carcinogenic individual risk in the city territories under study is identified in adolescents and adults in the 2nd zone (0.00426 and 0.00298). The value of total carcinogenic risk (TCR) in the territories under study on complex multi-environmental ingestion of CSs (chemical substances) in the adolescent and the adult population corresponds to the alarming risk level (1.0 � 10-3 � 1.1 � 10-4). Chloroform and lead make the major contribution to the value of carcinogenic risk in all zones. Calculation of the carcinogenic risk levels for all carcinogenic substances was made with application of standard values and regional exposure factors at the �� and the 95th Perc levels. Assessment of carcinogenic risk was carried out for 3 (three) substances contained in drinking water: cadmium, lead, chloroform. The total carcinogenic risk for adolescents on exposure to carcinogens contained in water REFMe and REF95 Perc was allowable in all zones. Differences in the value of carcinogenic risk levels made 0.107 � 0.227 at EF��/SEF and 2.0 at EF 95 ��rc/SEF. The major contribution to the value of carcinogenic risk was made by chloroform and lead in all zones. We can assume that in majority of cases the main contribution is made by chloroform in the 3rd district and metals- in the 4thone. The highest carcinogenic risk level is registered at the 95th �erc level for the adolescent health in all zones under study. Differences in regional and standard values of EF have impact on the population health risk levels. Analysis of the risk levels with application of local factors and age differences in exposure to chemicals ingested perorally with drinking water showed that the use of standard values in the methodology of risk assessment resulted in underestimation of actual carcinogenic risk for adolescents.