Comparative Cephalometric Study of Nasal Cavity Growth Patterns in Seven Animal Models

Abstract

Although primates have been the craniofacial growth models of choice, recent circumstances have stimulated the search for nonprimate models. In a series of studies we have described changes in various regions of the craniofacial complex for seven commonly used animal models. The present study examined the bony nasal cavity. One hundred and forty-four serial and cross-sectional lateral head x-rays were obtained for unoperated controls from previous growth studies. The sample consisted of data from 26 rats, 21 rabbits, 21 domestic cats, 23 domestic dogs, 17 baboons, 16 rhesus monkeys, and 20 chimpanzees. Comparative human data was taken from the Bolton Standards. The samples were divided into three age categories based on dental and somatic development. Midsagittal nasal cavity measurements included length, height, shape index, and area. Analysis was based on the percent increase in measures from the infant condition. Three major shapes were discerned at adulthood (1) vertical quadrangles (humans and cats); (2) triangles (chimpanzees, rhesus monkeys, and baboons), and (3) horizontal quadrangles (rabbits, rats, and dogs). Results showed that overall shape was best modeled by the chimpanzee and, as a nonprimate model, the laboratory cat. Rabbits and rats also showed similar percent changes for length or height dimensions at different ages, suggesting that these animals may be acceptable, inexpensive alternatives to primates in some experimental situations.