Abstract
Bile acids and bile alcohols are termed cholanoids. Biles of evolutionarily primtive vertebrates such as fishes, amphibians, and reptiles contain bile alcohols and higher bile acids in place of C24 bile acids in mammals. These higher cholanoids have the C24 bile acid type of nuclear structure and all or part of the side chain of cholesterol. The chemical structure, the natural distribution, and the biosynthetic pathways of bile alcohols and higher bile acids were studied. The results indicate that these compounds are evolutional precursors of the C24 bile acids found in mammalian species and the mechanism of the conversion of cholesterol to the C24 bile acids in mammals is a recapitulation of the evolution of cholanoid molecules.
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Schedule a callMore From: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
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