Abstract
This study compares beta‐blocking effects and effects on urinary sodium excretion of propranolol and sotalol, a new beta blocker. All subjects received a liquid, 100 mEq. sodium diet. Acute effects were studied in 4 normal men who received graded daily doses (5 to 1,280 mg. orally) of the 2 beta blockers after a control period in a crossover design. Subacute effects were studied in 2 groups of 6 men who received 2 doses of each drug for 4 days. Both propranolol and sotalol produced dose‐related attenuation of the increases in heart rate and decreases in diastolic blood pressure during isoproterenol infusions. Neither drug appreciably altered 24 hour urinary sodium, potassium, or creatinine excretion. Both drugs reversed the day‐night ratio of urinary sodium excretion, but propranolol produced this effect at a lower dose level than sotalol. Reversal of the day‐night ratio was not dose related with either drug and could not be directly correlated with beta blockade.
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