Comparative assessment of blood gas composition in children with cerebral ischemia during single and course application of physical factors

Abstract

Introduction (relevance): Cerebral ischemia (CI) is damage to the brain tissue resulting from prolonged insufficient oxygen supply. CI occupies one of the leading places in the structure of morbidity in terms of frequency and significance, accounting for up to 60-80% of all diseases of early childhood and ranking first in the structure of childhood disability. Currently, an active search and development of new, pathogenetically substantiated, non-drug methods of treatment is underway. The purpose of the study: to study the effect of general magnetic therapy and hyperbaric oxygen therapy on the blood gas composition in children with cerebral ischemia against the background of a single and course application of physical factors. Material and methods: The results of treatment of 150 children in the first month of life with cerebral ischemia of moderate severity and intracranial hypertension syndrome, who underwent the inpatient stage, were analyzed. Depending on the treatment complex used, the children were divided into three statistically homogeneous groups of 50 people each. The patients of the main groups received physiotherapy treatment along with the standard complex. The patients of the main group I were prescribed general magnetic therapy (GMT) along with the standard complex. The patients of the main group II received basic therapy for this pathology and consecutive courses of general magnetic therapy and hyperbaric oxygen therapy (HBOT). In the course of the work, the acid-base status of capillary blood was studied. The analysis of the study results and the construction of tables and charts were carried out using the Microsoft Office 2010 office suite, the Statistica 6.0 statistical software package, and evidence-based medicine methods. Results: A comparative analysis of a single effect of various therapeutic methods on impaired acid-base balance indicators revealed a significant advantage of hyperbaric oxygen therapy in eliminating the phenomena of metabolic acidosis. The results obtained during the course administration of physical factors reliably prove the absence of a relationship between the elimination of the phenomena of metabolic acidosis, which aggravates the post-hypoxic recovery of the child's brain tissue, and the chosen therapeutic tactics for the course CI treatment, having an equivalent effect on the neurological rehabilitation of patients. Conclusion: The therapeutic effect of general magnetic therapy and its complex with hyperbaric oxygen therapy became a trigger factor for the activation of tissue respiration and cellular metabolism and led to a significant elimination of metabolic acidosis in most patients. The leading position as a catalyst for the metabolic and respiratory processes of the cell is occupied by hyperbaric oxygen therapy, which contributes to the normalization of the acid-base status of the blood in children with CI even after a single application, compared to basic therapy and general magnetic therapy.