Abstract
With the emergence of multidrug-resistant pathogens, the antimicrobial property of silver in colloidal form has become an efficient drug for fighting infectious diseases. However in vivo safety evaluations have been needed to evaluate wound healing, hematological assessment, and toxicity analysis for infection caused by S. aureus. In this study, bacteriocin and bacteriocin capped silver nanoparticles (BCSNPs) were evaluated for 16 days and compared with cephalexin antibiotics for wound healing properties. The wound healing efficacy of antibiotic (cephalexin) treatment was a little bit lower than that of treatment with bacteriocin and BCSNPs at the end of the study. In vivo assessments indicated no significant changes in serum biochemical analysis and no abnormalities or damages to major organs after treatment with bacteriocin and BCSNPs. Taken together bacteriocin and BCSNPs hold a lot of promise as a safe antimicrobial treatment for treating MRSA infections.
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