Comparative assesment of prognosis and frequency of acute inflammatory demyelinating polyneuropathy in Turkish and Syrian patients between 2012 AND 2018

Abstract

To compare the frequencies and prognoses of the Turkish and Syrian patients diagnosed with, and treated for acute inflammatory demyelinating polyneuropathy (AIDP). The whole data of 40 patients with AIDP, 20 Turkish and 20 Syrian, who have been hospitalized between 2012–2018 in the Neurology Clinic of Mustafa Kemal University Medical Faculty, have been evaluated retrospectively, and analyzed. The average age were 43,65 ± 13,95. In 60% of the patients, upper respiratory infection has been detected as most common factor. The admission time to hospital for Syrian patients was 11,3 ± 5,7 days, it was 6,5 ±4,0 days for the Turkish patients, and the difference was significant. The hospitalization and discharge MRC scores in Turkish patients were higher and the difference was statistically significant (p < 0,001). While the Syrian patients with 3 or below AIDP disability (Hughes) score was 30%, it was 100% in Turkish patients (p < 0,001). Hyponatremia, low hospitalization MRC score, late admission to hospital are determined as bad prognostic factors. In Syrian patients, hyponatremia was seen more respect to Turkish patients. The hospitalization-discharge MRC scores of Syrian patients were lower, and Hughes scores were higher respect to Turkish patients. In Syrian patients the need of intensive care and sequel ratio was higher, while the response to treatment was higher in Turkish patients. In Syrian patients, AIDP progresses with worse prognosis than Turkish patients, and their response to treatment is worse. We hypothesize that AIDP can be seen easier due to the suppression of the immunological picture during and after the war.