Abstract
Ion transport in both the frog skin (a high-resistance epithelium) and the rabbit nasal airway epithelium (a low-resistance epithelium) are dominated by electrogenic Na + absorption via apical membrane amiloride-sensitive Na + channels, and short-circuit current (I SC) is essentially a measure of Na + absorption in both epithelia. In both epithelia, mucosal application of the short-chain phospholipid didecanoyl-L- α-phosphatidylcholine (DDPC) dose-dependently inhibited the amiloride-sensitive I SC and caused an initial decrease in epithelial conductance (G t) followed by an increase in G t to steady-state values above control level. The effects were reversible. It is concluded that DDPC (a) inhibits epithelial amiloride-sensitive Na + channels and (b) induces an increase in paracellular tight junction conductance. These effects may involve changes in non-specific lipid-protein interactions at the cell membrane level.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Comparative Biochemistry and Physiology -- Part A: Physiology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
