Abstract
1. 1. The antiulcer activity (ethanol or indomethacin-induced ulcers) and the antisecretory effects (pylorus-ligated rats) of various selective and non selective calcium antagonists were studied. 2. 2. Flunarizine and pirenzepine reduce the ethanol-ulcer length whereas diltiazem and cimetidine are weakly active and verapamil, nifedipine and nicardipine are ineffective. 3. 3. All tested compounds except verapamil prevent the development of indomethacin-induced ulceration. 4. 4. All substances, except flunarizine decrease the total H + output in Shay rats. 5. 5. The activities of the different compounds are discussed in terms of their mode of action.
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