Abstract
The objective of this study was to evaluate the in vitro activity of sparfloxacin, levofloxacin, ofloxacin, and ciprofloxacin against contemporary strains of streptococci. Susceptibility testing of a panel of 300 recent clinical isolates of streptococcus (100 each of β-hemolytic, viridans group, and Streptococcus pneumoniae) using reference broth microdilution methods was performed, and the results were compared. Sparfloxacin was the most active of the four tested fluoroquinolones, inhibiting 99–100% of all isolates at concentrations of ≤1 μg/ml, and was two- to eightfold more potent than the three comparative agents. Levofloxacin was also quite active, inhibiting 98–100% of the isolates at concentrations ≤2 μg/ml. Both sparfloxacin and levofloxacin possess an improved spectrum and potency against contemporary strains of streptococci compared to currently available fluoroquinolones.
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