Abstract
Comparative Anticonvulsant Activity of Leaf, Stem Bark and Root Bark Extracts of Bombax costatum Pellegr. and Vuillet in Acute Models of Epilepsy
Highlights
Epilepsy is a well-known chronic neurological illness that disturbs people of all ages and has a universal dissemination.[1,2] The fundamental indication of the disease is epileptic seizures; which is characterized by spontaneous and recurrent episodes of abnormal firing of a neuronal population and disturbances of consciousness.[3,4] As stated by the World Health Organization (WHO), about 50 million people have active epilepsy, making it one of the frequent neurological disorder that largely affects individuals in low and middle-income countries.[2]
Scientific reports on the anticonvulsant activity of B. costatum are scarce despite its wellcommended efficacy and acceptability in the management of epilepsy
The leaf, stem bark and roots of B. costatum have been utilized in African Traditional Medicine in the remedy of epilepsy
Summary
Epilepsy is a well-known chronic neurological illness that disturbs people of all ages and has a universal dissemination.[1,2] The fundamental indication of the disease is epileptic seizures; which is characterized by spontaneous and recurrent episodes of abnormal firing of a neuronal population and disturbances of consciousness.[3,4] As stated by the World Health Organization (WHO), about 50 million people have active epilepsy, making it one of the frequent neurological disorder that largely affects individuals in low and middle-income countries.[2]. B. costatum is found largely in the Savanna areas of West Africa It is commonly recognized in English as red-flowered silk cotton tree and in Nigerian languages as “Gurjiiyaa”, “Joohi” and “Akpu” (in Hausa, Fulfulde and Igbo, respectively).[13] Different parts of B. costatum are used in ethno-medicine against many ailments including epilepsy, oedema, hernia, headache, fever, insanity, skin diseases, yellow fever, diarrhoea and liver problems.[13,14,15] Basically, the powdered plant parts are macerated and eaten in a sauce or applied as a bath against epilepsy.[15] Scientific investigations have reported that B. costatum possesses antioxidant, anti-inflammatory and hepatoprotective activities.[12,16,17] To our knowledge, scientific reports on the anticonvulsant activity of B. costatum are scarce despite its wellcommended efficacy and acceptability in the management of epilepsy. Official Journal of Natural Product Research Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
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