Abstract
a peer-reviewed, open access online international journal which publishes original research papers. The journal welcomes submission from scholars and experts for possible publication from all over the world. The scope of the journal includes: Pharmaceutical research, chemistry and biochemistry of naturally occurring compounds, biological evaluation of crude extracts, ethnomedicine, traditional and complementary medicine, ethnopharmacology, biomedical research, Biotechnology, Evaluation of natural substances of land and sea and of plants, microbes and animals, pharmacognosy, bioavailability, clinical, pharmacological, toxicological studies and pharmacokinetics of phytochemicals, Isolation and characterization of compounds, structure elucidation, synthesis and experimental biosynthesis of natural Product as well as developments of methods in these areas are welcomed in the journal.
Highlights
Uropathogenic E.coli (UPEC) is a common pathotype of extraintestinal pathogenic E.coli (ExPEC) which greatly emanates from intestinal microbiota.1ExPEC has been implicated to cause bacteremia in older adults, meningitis in neonates and the majority of urinary tract infections (UTIs) in young healthy women.[2]
The biosynthesized AgNPs in this study was primarily characterized using UV-Vis spectrophotometer and an absorption peak of 450 nm was observed, which is typical of AgNPs as they usually display a surface Plasmon resonance band ranging from 400-550 nm .18,49,50,51An absorption spectra of 450 nm has been reported for several biosynthesized AgNPs.[44,52,53]
This study has revealed that silver nanoparticles can be synthesized in a simple and cost effective method using aqueous extract of unripe pawpaw peel
Summary
Uropathogenic E.coli (UPEC) is a common pathotype of extraintestinal pathogenic E.coli (ExPEC) which greatly emanates from intestinal microbiota.1ExPEC has been implicated to cause bacteremia in older adults, meningitis in neonates and the majority of urinary tract infections (UTIs) in young healthy women.[2] Estimation shows that 40-50% of women and 5% of men will develop a UTI in their life time.[3] an increase in morbidity and mortality rates caused by UTI are due to untreated or mistreated UTI which results in kidney and systemic infections .1. The extended usage of last-line antibiotics as a result of recurrence of infection causes resistance to antibiotics.[4] This rise in antibiotics resistance of ExPEC has hindered the effective management of UTI.[5] The tactics used by this pathogenic bacteria to evolve antibiotics resistance includes active efflux of drugs, variation of target sites and degradation of enzymes .6. The tactics used by this pathogenic bacteria to evolve antibiotics resistance includes active efflux of drugs, variation of target sites and degradation of enzymes .6 Since medicinal plants contain a wide variety of secondary metabolites, they are being promoted as alternate source of antimicrobials and resistance modifying agents.[7,8,9] Recently, phenolic compounds found in plant has been implied to show significant antimicrobial activity,[10,11,12] and have the ability to attack multidrug
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