Abstract
SummaryBackgroundInflammatory responses as a result of carbohydrate (CHO) engorgement have been associated with peripheral tissue insulin resistance.ObjectivesThe aim of this study was to comparatively evaluate the anti‐inflammatory effects of intravenous (i.v.) administration of insulin and dexamethasone on clinical parameters, antioxidants and cardiovascular biomarkers in miniature donkeys subjected to induced CHO overload.Study designProspective, experimental study.MethodsEighteen clinically healthy male miniature donkeys with the age of 5 ± 1 years, weight of 105 ± 6 kg, body condition score of 5 (moderate) and height at the withers of 0.9 ± 0.06 m were used for this study. The animals were randomly assigned into three experimental groups (2 treatments and 1 negative control). Oligofructose (OF) at 10 g/kg of bodyweight was administered via nasogastric tube to induce CHO overload. Six hours later, animals in the treatment groups received IV 3 IU/kg bwt of insulin and 2 mg/kg bwt dexamethasone, respectively.ResultsThe results of this study revealed that heart rate (HR), respiratory rate (RR) and rectal temperature (RT), packed cell volume (PCV), white blood cell (WBC), glucose, homocysteine (Hcy) and cardiac troponin I (cTnI) increased, while the values of superoxide dismutase (SOD) and glutathione peroxidase (GPX) decreased in miniature donkeys subjected to CHO engorgement. All variables (except PCV) returned to normal values within 24 h in treatment groups. In treatment groups, HR and RR were significantly lower than the control group after 12 h. There were no significant differences between insulin and dexamethasone in levels of cTnI, Hcy, SOD, GPX, glucose, PCV and WBC after 24 h.Main limitationsRecording of only antioxidants and cardiovascular biomarkers is insufficient to well define the anti‐inflammatory effects of insulin.ConclusionsIt could be suggested that insulin (3 IU/kg bwt) and dexamethasone (2 mg/kg bwt) may be useful during CHO overload in miniature donkeys.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
