Abstract
The present study was designed to investigate the comparative effects of aqueous leaf extract of Ocimum gratissimum Linn. (Lamiaceae), vitamin C and vitamin E on the basal serum phosphatases- alkaline phosphatase (ALP), total acid phosphatase (ACPT) and prostatic acid phosphatase (ACPP) of the male guinea-pig. Also investigated were theinteractive effects of these agents on the biochemical parameters. Adult male guinea-pigs were divided into nineteen groups of five animals each and orally administered with different doses of O. gratissimum (11-352 mg/kg), vitamin C (1.25-80 mg/kg), vitamin E (75-2400mg/kg) and the last group (control) was given distilled water. Animals were sacrificed after 4h and blood samples collected and analyzed for ALP, ACPT, and ACPP. In another set of animals, O. gratissimum was administered 1h before obtaining the dose-responses of vitamins C and E and vice versa. O. gratissimum (11-352mg/kg), vitamin C (1.25-80mg/kg) and vitamin E (75-2400mg/kg) caused significant (p
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