Comparative analysis on clinical features of necrotizing enterocolitis in premature infants and full-term infants

Abstract

Objective To compare the clinical features of necrotizing enterocolitis (NEC) between premature infants and full-term infants, and provide theoretical basis for treatment of NEC. Methods This study used retrospective analysis. A total of 110 children with NEC admitted to Huangshi Central Hospital from March 2015 to March 2018 were selected. All children were divided into preterm group (n=95) and full-term group (n=15) according to child birth gestational age. The clinical data were analyzed, and the clinical manifestation, complications and clinical features, laboratory results and perinatal factors of the two groups were compared. Results The morbidity of NEC in preterm group was higher than that in full-term group, and the difference was statistically significant (P 0.05). The main clinical manifestations of NEC children were hematoplegia and abdominal distension, and the risk of postoperative bowel perforation and urinary retention was high. The incidence of apnea, premature rupture of membranes, and reduction of hemoglobin in preterm group were all higher than those in full-term group, and the difference was statistically significant (P<0.05). Conclusions There are some differences in the prevalence, clinical manifestations, perinatal factors and laboratory examinations of NEC between premature and full-term infants. And clinical condition should be analyzed in combination with gestational age of children, and the early risk assessment of NEC in premature infants should be strengthened. It is necessary to make diagnosis and intervention as early as possible to reduce mortality and improve prognosis. Key words: Necrotizing enterocolitis; Premature infants; Full-term infants; Clinical features