Abstract
Vitamin D is an important prehormone which deficiency is recognized as a pandemic with many adverse effects on human health at the beginning of intrauterine development period. Vitamin D deficiency is associated with placental insufficiency, fetal growth retardation syndrome, miscarriage, preeclampsia, gestational diabetes, low birth weight, increasing of autoimmune diseases. A study of pretenatal provision of vitamin D in newborns in the Volgograd region has not been carried out yet. Materials and methods: the 25(OH)D levels in the umbilical cord blood serum of 118 newborns was performed, then babies were randomized to 2 groups depending on their gestational age: the 1st group included preterm infants of gestational age from 24 to 36 weeks (n = 52); the 2nd group contained full-term newborns born from 37 to 41 weeks (n = 66). The analysis of socio-demographic and medical indicators characterizing the course of the prenatal period of a child's life was carried out. Pathomorphological features of the placenta and umbilical cord were compared according to pathological and morphometric data in the studied groups. Results: the proportion of premature babies with a 25(OH)D deficit is significantly higher than that of full-term babies (69,2 and 38,2 %, respectively, p < 0,001). Significant differences were found in the group of preterm infants in compare to full-term ones due to: gestational age, low Apgar score; low birth weight and body length, fetus-placental insufficiency and umbilical cord abnormalities (p < 0,05). Conclusions: the study showed the dependence of 25(OH)D deficiency on umbilical cord blood on gestational age, low birth weight and body length, low Apgar score, fetus-placental insufficiency, umbilical cord disease, maternal arterial hypertension during pregnancy. Further study of the predisposition to low prenatal provision of vitamin D in newborns babies in the Volgograd region is necessary.
Highlights
Витамин D является важным прегормоном, дефицит которого признан пандемией с множеством неблагоприятных последствий для здоровья человека, начиная с периода внутриутробного развития
Vitamin D deficiency is associated with placental insufficiency, fetal growth retardation syndrome, miscarriage, preeclampsia, gestational diabetes, low birth weight, increasing of autoimmune diseases
Materials and methods: the 25(OH)D levels in the umbilical cord blood serum of 118 newborns was performed, babies were randomized to 2 groups depending on their gestational age: the 1st group included preterm infants of gestational age from 24 to weeks (n = 52); the 2nd group contained full-term newborns born from to 41 weeks (n = 66)
Summary
Витамин D является важным прегормоном, дефицит которого признан пандемией с множеством неблагоприятных последствий для здоровья человека, начиная с периода внутриутробного развития. Significant differences were found in the group of preterm infants in compare to full-term ones due to: gestational age, low Apgar score; low birth weight and body length, fetus-placental insufficiency and umbilical cord abnormalities (p < 0,05). Conclusions: the study showed the dependence of 25(OH)D deficiency on umbilical cord blood on gestational age, low birth weight and body length, low Apgar score, fetus-placental insufficiency, umbilical cord disease, maternal arterial hypertension during pregnancy.
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