Comparative Analysis of the Use of Domestic Bioresorbable Collagen Membranes at the Closure of Postoperative Defects of the Oral Mucosa in an Experiment In vivo

Abstract

The success of using soft tissue transplants is enough for their spreading in the clinic, but the need to cover the surface, where the transplant was taken from, can be forgotten. It can lead to long-term discomfort of the patient in real life, in some cases to complications alike bleeding; We performed the analysis of the use of different new xenogenic resorbable membranes created within our University in compare with the natural healing of oral mucosa defects in the experiment in vivo on 36 rabbits after performing of the surgical wound on the palatine side (5x5 mm). All animals were separated (divided) for 3 groups: #1 group of control and main groups #2 and #3, where we used pericardium and collagen film for covering mucous defects. We assessed the edema, hyperemia in the operation side, the pain according to animal behavior, the histological picture after animals completion of the experiment (on 3rd, 6th and 10th days); The decrease of clinical signs of inflammation in groups of collagen and pericardium films use (p<0.05) was statistically confirmed. Analysis of histologic investigation of biopsy specimens has shown the faster and massive growth of soft tissue in the donor site after application of pericardium and collagen films (p<0.05). An analysis of the experiment results allows recommending their possible use for closing the donor site after taking a free gingival graft or in the zone of postoperative wound defect in the oral mucosa in clinical oral surgery after specific clinical trials.