Comparative Analysis of the Stress Protective Effect of Lithium Salts in an Open Field Test

Abstract

Systemic response to stress, aimed at eliminating or reducing stress, is accompanied by changes in behavioral, vegetative, motor, sensory, cognitive, and other bodily functions. Stress behavior is an integral part of general behavior. In this work, we set out to study the behavioral activity of rats in an open field test following administration of various lithium salts. The conducted experiments showed that a course application of organic lithium salts improves the motivational characteristics of behavior and the appearance of rats, significantly increases the tentative research behavior of experimental animals, and reduces the level of anxiety, fear, and uncertainty, which can be characterized as an adaptive-stimulating effect. At the same time, the drug demonstrates a cumulative effect. The anabolic effect of lithium orotate is particularly pronounced, which makes it possible to increase body weight gains in the setting of stress of various etiologies.