COMPARATIVE ANALYSIS OF THE INFLUENCE OF COMPLEX MIXTURES OF CHEMICAL AIR POLLUTANTS ON BIOCHEMICAL, PHYSIOLOGICAL, GONADO-, EMBRYOTOXIC INDICES OF LABORATORY ANIMALS AND HYGIENIC EVALUATION OF THEIR COMBINED ACTION

Abstract

In the paper there are presented results of experimental works on the study of the character of the combined toxic effect of various complex mixtures presenting in atmospheric air. The action of complex mixtures on the organism of laboratory animals was studied in two series of experiments. In the first series of the experiments there was investigated the combined action of sulfur dioxide, nitrogen dioxide, hydrogen fluoride and suspended substances, and in the second series of experiments - of lead acetate, formaldehyde, sulfur dioxide and ammonia.The character of the combined action of lead acetate, formaldehyde, sulfur dioxide, ammonia under one-term inhalation is established to be manifested in the form of “effect-summation”, and the impact of such suspended substances as hydrogen fluoride, sulfur dioxide, nitrogen dioxide was similar to the type of “incomplete summation”. In the joint presence of lead acetate, formaldehyde, sulfur dioxide, ammonia in the ambient air, the maximum permissible concentration (MPC ) for each substance should not exceed 0.25 MPC, and the hydrogen fluoride, nitrogen dioxide, sulfur dioxide and suspended solids should not exceed 0.46 MPC under their isolated action .