Abstract
BackgroundA comparative analysis of the genomic and replication profiles of different geographical chikungunya virus (CHIKV) isolates of the East, Central and South African (ECSA) lineage was performed.FindingsAnalysis of the data revealed the different growth kinetics for the different isolates. Deep genome sequencing analysis further revealed specific amino acid mutations in the viral nsP1, nsP3, nsP4, E1 and E2 proteins in the different isolates. Despite the difference in viral genomic profiles, the virus-induced ultrastructural changes within infected cells remained highly conserved among the different chikungunya virus isolates.ConclusionsThese findings provide insights into the genomic and replication profiles of the re-emerging chikungunya virus isolates of the ECSA lineage.
Highlights
A comparative analysis of the genomic and replication profiles of different geographical chikungunya virus (CHIKV) isolates of the East, Central and South African (ECSA) lineage was performed
Chikungunya virus (CHIKV) was first isolated following an outbreak in Tanzania in the 1950s [1]
CHIKV infection typically induced an acute onset of painful syndrome as characterised by polyarthralgia, fever, asthenia, headache, myalgia and skin rashes [2,3]
Summary
Comparative analysis of the genome sequences and replication profiles of chikungunya virus isolates within the East, Central and South African (ECSA) lineage. Karen Caiyun Chen, Yiu-Wing Kam, Raymond Tzer Pin Lin, Mary Mah-Lee Ng4, Lisa FP Ng2 and Justin Jang Hann Chu1*
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