Comparative Analysis of the Functional Properties of Films Based on Carrageenans, Chitosan, and Their Polyelectrolyte Complexes

Aleksandra V. Volod’ko,Dmitry P. Romanov,Evgeniya A. Pimenova,Viktoriya N. Davydova,Valentina A. Petrova,Irina M. Yermak

doi:10.3390/md19120704

Abstract

The influence of the structural features of carrageenan on the functional properties of the films was studied. The carrageenans and chitosan films, as well as three-layer films containing a polyelectrolyte complex (PEC) of the two, were prepared. The X-ray diffractograms of carrageenan films reflected its amorphous structure, whereas chitosan and three-layer films were characterized by strong reflection in the regions of 20° and 15° angles, respectively. The SEM of the cross-sectional morphology showed dense packing of the chitosan film, as well as the layer-by-layer structure of different densities for the PEC. Among the tested samples, κ/β-carrageenan and chitosan films showed the highest tensile strength and maximum elongation. Films containing the drug substance echinochrome were obtained. Mucoadhesive properties were assessed as the ability of the films to swell on the mucous tissue and their erosion after contact with the mucosa. All studied films exhibited mucoadhesive properties. All studied films exhibited mucoadhesive properties which depended on the carrageenans structure. Multilayer films are stronger than single-layer carrageenan films due to PEC formation. The resulting puncture strength of the obtained films was comparable to that of commercial samples described in the literature.

Highlights

Thin films are a novel drug delivery tool and have been used as an alternative dosage form [1]
The structures of the polysaccharide fractions were studied by NMR and FTIR-spectroscopy
An increase in the mechanical properties of films due to the formation of polyelectrolyte complex (PEC) leads to a decrease in their swelling ability

Summary

Introduction

Thin films are a novel drug delivery tool and have been used as an alternative dosage form [1] They may be useful for reducing extensive metabolism and eliminating the side effects of a drug [2]. Ideal thin films should be nontoxic, biocompatible, and biodegradable They must have a sufficient drug-loading capacity and acceptable formulation stability, a fast dissolution rate, or a long residence time at the site of administration [4]. This delivery system has been used for both systemically and locally via several pathways, including the oral, buccal, sublingual, ocular, and transdermal routes of administration

Objectives

Methods

Results

Conclusion