Abstract
In the article of genetic studies of patients with post-covid maxillofacial complications. The condition after COVID-19 is considered a life-threatening disease, ranging from mild symptoms to serious complications. Candidiasis is the most common type of superficial purulent infection. The Candida species is a frequent inhabitant of the oral mucosa, but its growth is inhibited by other organisms in the body, which prevents any pathological change in the mucous membrane of this fungus. Candida albicans is the most common yeast, followed by Candida glabrata, Candida krusei, Candida tropicalis and Candida stellatoidea. According to this systematic review, 57 cases of oral candidiasis and one case of retinitis candidiasis were reported in patients undergoing treatment for COVID-19. Single-cell RNA-seq analysis of angiotensin-converting enzyme II (ACE2) expression and serologic examination of samples indicates that ACE2 may be the cellular receptor for SARS-CoV-2, suggesting that ACE2-expressing cells are likely to be the main target cell type that vulnerable to SARS-CoV-2 infection. As a rule, there is a high expression of ACE2 r on the epithelial cells of the oral mucosa, enrichment is enriched in epithelial cells of the tongue. There were few reports prior to this study.
Highlights
Mucormycosis is an angioinvasive infection characterized by tissue necrosis and blood vessel infarction [1]
These data allow us to conclude that the C allele and the T / T genotype of the rs1801133 677C> T polymorphism in the MTHFR gene, associated with a decrease in MTHFR production, have an insignificant predisposing effect on the development and clinical course of postcoid complications of MCL
Since this polymorphism is located in the promoter region of the gene and belongs to functional polymorphisms, it can be argued that its presence affects the rate of expression of the gene encoded by MTHFR
Summary
Mucormycosis is an angioinvasive infection characterized by tissue necrosis and blood vessel infarction [1]. A multicenter study in India identified diabetes, inappropriate steroid therapy (6 mg dexamethasone daily for 7-10 days is recommended; higher dose and longer duration of treatment are considered impractical) and COVID-19 virus as risk factors for increased incidence of mucormycosis during the first wave COVID-19 in 2020 [9]. During this outbreak, the most common manifestation was rhino-orbital-cerebral mucormycosis (ROCM), followed by pulmonary mucormycosis [6,9]
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