Abstract
Objective To evaluate the different modes of administration of paclitaxel and cisplatin in patients with advanced ovarian cancer.Methods From June 2011 to May 2013,100 cases of advanced ovarian cancer in our hospital were randomly divided into observation group and control group,50 cases in each group.Observation group used the intravenous infusion of paclitaxel plus cisplatin intraperitoneal treatment,while control group used paclitaxel and cisplatin administered intravenously.The clinical efficacy and the incidence of adverse reactions were observed and compared between two groups.Results The effective rate in observation group was 84％,while that in control group was 56％,with statistically significant difference in short-term efficacy between two groups (P ＜ 0.05).The incidence of leukopenia had no statistically significant difference between two groups (P ＜ 0.05).The incidences of nausea and vomiting,hair loss,kidney damage,muscle and joint pain in observation group were significantly lower than those in control group,with statistically significant differences (P ＜ 0.05).Conclusion Intravenous administration of paclitaxel plus cisplatin intraperitoneal treatment of advanced ovarian cancer has good efficacy,with fewer adverse reactions,which should be promoted in clinical practice. Key words: Paclitaxel; Cisplatin; Ovarian cancer; Efficacy
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