Comparative analysis of post operative analgesic requirement in patient undergoing minor oral surgery using buprenorphine with lignocaine versus lignocaine-a double blind study

Abstract

Aim: The aim of this study is comparative analysis of post operative analgesic requirement in patient undergoing minor oral surgery using 2% Lignocaine with 1:200000 Adrenaline and Buprenorphine versus 2% lignocaine with 1:200000 Adrenaline. Materials and Method: One hundred patients requiring minor oral surgery were included in the study. The patients were randomized by a third party and allocated to one of the two study groups. This allowed the patients and the operators to remain unaware of the group allocations. 1 ml of Buprenorphine Hydrochloride injection I.V which contains an equivalent of 0.3 mg Buprenorphine was withdrawn into a syringe and injected into a 30 ml vial of 2 % Lignocaine with Adrenaline 1:200000. Thus each ml of local anesthetic contained 0.01 mg of Buprenorphine. This solution was labelled and used for the study. Results: The duration of analgesia in Group I was found to be 13.71 ± 7.2 h and Group II was 39.58 ± the average consumption of NSAIDs was found to be 2.88 as compared to Group II mean value of 1.29 (P=0.0001). Conclusion: We concluded that addition of 0.3 mg of Buprenorphine to 30 ml Lignocaine with Adrenaline 1:200000 for minor oral surgery results in significant improvement in postoperative analgesia up to 39 h and markedly reduces the need for excessive analgesic intake. Thus reducing the adverse effects associated with excessive use of NSAIDs. Further studies needs to be done as there is less literature about Buprenorphine added to local anaesthetist. Keyword: Buprenorphine, Hydrochloride, Analgesia