Comparative analysis of optical coherent angiotomography in patients with primary open-angle glaucoma

Abstract

Objective: to conduct a comparative analysis of the parameters of the optic nerve head, retinal ganglion cells and microcirculation parameters in patients with primary open-angle glaucoma (POAG) of various stages in achieving the target intraocular pressure using the method of optical coherence angiotomography. Material and methods. 87 patients (87 eyes) with POAG were examined. Group 1 — 26 patients (26 eyes) with stage I POAG, group 2 — 19 patients (19 eyes) with stage II glaucoma, group 3 — 24 patients (24 eyes) with stage III glaucoma. Group 4 (control group) — 18 patients (36 eyes) without signs of glaucoma. Optical coherence tomography was performed on patients, angio-OCT scans 6.4x6.4 of the macula and optic nerve head were used. Results. The thickness of the nerve fiber layer (RNFL) was 94.00±10.54 urn in patients with stage I POAG, 48.00±1.00 urn and 41.00±1.73 urn in patients with stage II and III POAG, respectively, moreover, a more sensitive indicator is the RNFL in the lower peri-papillary zone (Inf RNFL). The thickness of the layer of retinal ganglion cells (RGCs) in patients with stage I POAG was 96.33±4.62 urn, with II — 70.33±1.53 urn, with III — 64.33±11.93 urn. The density of blood vessels in the area of the optic disc differed from the norm in patients with stages II and III of POAG (42.23±4.95 and 35.10±1.80, respectively). Conclusion. In patients with different stages of POAG, the greatest differences were found in RNFL in the lower segment, the area of the neuroretinal rim, the values of focal and global GCS loss, and the density of the vascular bed in the lower half of the peripapillary zone.