Comparative analysis of microbiota of oral fluid in patients with psychoneurological disorders using toothpaste with the enzyme «bromelain»

Abstract

Relevance. The complex of actions for decrease in growth of diseases of the maxillofacial region includes the reorganization of the mouth, creating an individual program for hygiene and prevention. Among the large number of types of therapeutic and preventive hygiene products for patients with neuropsychiatric disorders, given the burdened somatic status, the program should include safe for use basic and additional means.Purpose. Comparative assessment of oral fluid microorganisms in patients with psychoneurotic disorders before and after 6 months of using toothpastes with the enzyme «bromelain».Materials and methods. A comparative analysis of the oral fluid microflora in patients with high intensity and activity of the cariosity, with positive (psychoneurological disorders) anamnesis and without comorbidities has been carried out. The mouths of all studied patients were sanitized, and a program of personal oral hygiene using hygienic toothpastes and with the enzyme «bromelain» was developed.Results. The conducted research does not prove the bactericidal effect of the enzyme «bromelain» on oral microflora, however, a significant decrease of the total number of viable bacteria, changes in the species composition, and the degree of hemolecular properties indicates an indirect bacteriostatic effect of this enzyme in the composition of the toothpastes, which can be considered as a positive effect on the decrease of caries activity in patients with «negative» dental status (caries intensity index > 9, hygiene index by the method of Yu.A. Fedorov and V.V. Volodkina > 2 points, 3rd degree of caries activity by T.F. Vinogradova), including in patients with psychoneurological disorders.Conclusion. The use of enzyme «bromelain» in toothpastes in patients with neuropsychiatric disorders contributes not only to the safe and intensive cleavage of soft plaque, but also to a positive effect on the microbiota of the oral fluid, which is a favorable prognostic criterion for reducing the activity of the carious process.