Comparative analysis of mettaloproteinase system and their tissue inhibitors at periodontitis in patients with diabetes mellitus type II

Abstract

The article presents the results of a comparative study of the systemic and local levels of matrix metalloproteinases MMP-2, MMP-8, MMP-9 and their tissue inhibitors TIMP-1, TIMP-2 in patients with periodontitis and type II diabetes (group I) and periodontitis without diabetes mellitus (group II). 65 patients were examined, including: 30 patients. – I group and 35 people. – II group. The control group consisted of healthy volunteers (30 people). In both patients, a signifi cant increase in MMP-9, TIMP-1, -2 in the serum, an increase in MMP-2, -8, -9, TIMP-1, -2 in saliva, as well as MMP-8 and MMP-9 in the blood obtained from the microcirculatory bed of the gingival patients. A decrease in MMP-2 and MMP-8 levels in the blood serum, as well as a decrease in the levels of MMP-2 and TIMP-2 in the blood, obtained from the ICR of the gingiva in patients of groups 1 and 2, was determined. In patients with periodontitis against diabetes mellitus II, hyperproduction of MMP-9 was established, as well as an increase in the levels of TIMP-1 in blood obtained from the ICR of the gum. In the group of patients without concomitant pathology, on the contrary, there was a more pronounced increase in MMP-8 levels, as well as an increase in TIMP-1 in saliva and TIMP-2 in serum.