Abstract

Objective: The study was conducted to simultaneously display and compare the basic haematological indices (packed cell volume, total and differential white blood count) of subjects with different haemoglobin genotypes. The objective was to highlight the differences which may help in planning interventions and predicting outcomes. Study Design: An outpatient population-based retrospective study was performed. The study covered the period between 1987 and 2011 (25 years). The packed cell volume, haemoglobin genotype, total and differential white blood counts of three hundred and sixty subjects (180 males and 180 females) aged between 1 and 25 years were scrutinized. Only outpatients presenting for malaria were included for comparable morbidity. Patients with co-existing persistent HbF were excluded to avoid misinterpretation of the generated data. Results: There were significant differences between the haematological indices of the haemoglobin genotypes reviewed in the study. Conclusion: The Hb genotype should be routinely ordered alongside the other tests and the results interpreted with reference to the Hb Genotype.

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