Comparative analysis of features of microenvironment, stem cell and epithelial-mesenchymal transformation of non-invasive papillary bladder carcinoma with invasive carcinoma

Abstract

Invasive urothelial carcinoma is the most common bladder malignancy, comprising 90% of all primary bladder carcinomas. According to the statistics of Georgia, according to NCDC data, bladder cancer is the third most common cancer among men. It is more common in men than in women. This pathology takes the 9th place among the most common tumors in the world. Within the framework of our research, a cohort retrograde study was carried out, for which the archival material of the teaching-scientific and diagnostic laboratory of Tbilisi State Medical University for the years 2019-2021 was used. The markers of epithelial-mesenchymal transformation in low- and high-grade non-invasive urothelial carcinomas and invasive urothelial carcinomas, as well as characteristics of the internal tumor microenvironment and stem cell characteristics, were studied. Bladder carcinoma belongs to the heterogeneous group of tumors that have different rates of recurrence, progression and metastasis; It is necessary to develop markers that can be prognostic indicators in bladder tumors, which will greatly improve the clinical management of this type of tumors.