Abstract
During a long-term (7-day) continuous exposure of rats to β-endorphin from an implanted minipump by the subcutaneous route, changes in their motor activity (stereotypy) and pain sensitivity (hypoalgesia) were similar, though less marked, than those observed during such exposure by the intracerebral route, whereas the change in feeding behavior with the subcutaneous (peripheral) route of β-endorphin administration (hyperphagia) was opposite to that seen with intracerebral administration (hypophagia).
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