Comparative analysis of different factors associated with hypertension between subjects with and without gout

Abstract

Objective To compare and analyze different factors that influence hypertension between subjects with and without gout, and to recognize and understand them further. Methods A total of 7 395 patients(6 935 males and 460 females)from the gout clinic of Affiliated Hospital of Qingdao University between May 2009 and January 2016 were chosen as gout group, while 8 379 people without gout(7 858 males and 521 females)were served as control group. The height, weight, waist circumference, hip circumference, blood pressure, fasting plasma glucose(FPG), triglyceride(TG), cholesterol(TC), blood urea nitrogen(BUN), creatinine(Cr), and uric acid(UA)of both groups were monitored. Clinical and biochemical differences of the two groups were analyzed. The morbidity rate of hypertension in the two groups was also compared. According to different criteria, the subjects were divided into several subgroups. The data were analyzed mainly by Empower statistical software. Results The risk ratio of hypertension in gout group was 63.25%, and it was higher than that in control group(49.19%, χ2=316.25, P<0.01). The risk ratio of hypertension in gout group was 1.173 times higher than that in control group. After adjusting UA, it would drop to 1.065 times, but the difference still remained significant. In groups with diabetes, hyperlipidemia, hypercholesterolemia, obesity, the risk ratio of hypertension increased by 13.7%, 15.3%, 21.8%, and 23.6% respectively, in gout group. FPG, TG, TC, BMI, and WHR were all associated with HP in both gout and normal groups, but Cr was associated with HP in gout group only(OR=1.396, 95%CI 1.197-1.629). Age had different saturation effects in two groups. Conclusion The factors influence hypertension differently in patients with and without gout, especially those of gout itself and creatinine. The precision medicine should be applied. (Chin J Endocrinol Metab, 2017, 33: 98-102) Key words: Hypertension; Gout; Related factors; Comparative analysis