Abstract

Comparative Analysis of Conventional and Thin Prep Papanicolaou Test. Technical and Economic Aspects

Highlights

  • Cervical cancer is the fourth most common cancer and a leading cause of death due to cancer, in female population worldwide

  • Liquid Based Cytology (LBC) Papanicolaou test presents significantly better performance characteristics than the conventional test, it enables the application of modern ancillary examinations relevant to the human papillomavirus (HPV) lifecycle and the associated extra cost for the gained life years is significantly low

  • More than 85% of these cases and deaths are in developing countries; this is due to lack of screening that may allow detection of precancerous and early stage cervical cancer

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Summary

Introduction

Cervical cancer is the fourth most common cancer and a leading cause of death due to cancer, in female population worldwide. Since 90ies, this test can be performed via two methods: the conventional method, where cells are layered on a glass slide, immediately after their extraction and Liquid Based Cytology (LBC), where cells are stored in a vial containing a special liquid. Purpose of the study: To evaluate the performance of conventional and LBC Papanicolaou test in technical level, by assessing the diagnostic performance as well as the disadvantages of each method, and to carry out an economic evaluation via cost effectiveness analysis between the two methods. For this purpose we analyzed the results of 23,604 conventional tests and the equal number of LBC tests

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