Abstract
Objective: The objective behind this study is to evaluate the compliance and noncompliance, between standard therapy with latest oral anticoagulants (NOACs) with each other so as a head-to-head comparison will ever be available.
 Methodology: A descriptive observational study was conducted at SMBBMUH Larkana.The questionnaire (specially designed)was filled up to monitor the non-compliances associated with drugs used for the management of Deep Vein Thrombosis (DVT).The study was conducted on the 100 patients who were reported with DVT at tertiary care hospital SMBBMUH Larkana. A series of questions were asked from reported patients regarding symptoms and side effects. Finally the results were analyzed by using descriptive statistics.
 Results: Results show that out of 100 patients, male patients (79%) observed more than female(21%) and mostly patients perform indoor jobs (39%). Prevalence of DVT is high about 53% patients were suffering from DVT during 03 months. It was found that mostly patient non compliance observed with Warfarin (n=26) as compare to heparin (n=19) and Rivaroxaban (n=07).
 Conclusion: The study concluded that the more compliance achieved with Rivaroxaban as compared to warfarin and heparin. Mostly noncompliant factors are cost; prolong therapy, adverse drug reaction were common factors of non compliance in DVT patients.
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