Abstract
Objective To compare the clinical effect and side effects of gabapentin and duloxetine on diabetic peripheral neuropathic pain(DPNP).Methods Sixty-five patients with type 2 diabetes combined with DPNP admitted to the affiliated hospital of Heze medical college from February 2010 to August 2011 were randomly divided into two groups,the observation group were treated with duloxetine,and the control group received gabapentin,the pain were evaluated by visual analog scale (VAS).Resuits Compared with the VAS before treatment,the VAS scores after treatment on the 7 th,14 th and 28 th day of the two groups were significantly lower (P ＜ 0.01),there was no significant difference of the VAS scores between the two groups over the same period (P ＞ 0.05),and there was no significant difference between the two groups after administration of the same period in efficiency (P ＞ 0.05).The side effects of the observation group were significantly lower than that of the control group (P ＜ 0.01).Conclusions Gabapentin and duloxetine treatment of diabetic peripheral neuropathic pain had the desired therapeutic effect,but the side effects of duloxetine were significantly lower than that of gabapentin,and the patients' compliance is good and worthy of clinical application. Key words: Diabetic peripheral neuropathic pain; Gabapentin; Duloxetine hydrochloride; Clinical efficacy
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