Abstract

Comparative rates of cell proliferation in different areas of gastrointestinal tract of newborn hamster were estimated by observing the appearance of repetitive waves of 3HTdR labeled mitoses. The proliferation of cells was also studied by constructing theoretical models to simulate the appearance in time of the repetitive waves. In each model, the cycle durations of individual cells or groups of cells in the proliferating population, and the fractional contribution of each group to the total population were known. The contributions of the population elements were summated, to indicate descriptive characteristics of the repetitive proliferative cycles. The data indicated more rapid proliferation in small intestine than in stomach and colon, and suggested additional similarities and perturbations in the proliferative cycle of cells in these areas.

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