Comparative analysis of Bauhinia tomentosa L. and Kalanchoe pinnata Lam extracts with regard to their antinociceptive and antipyretic potentials in experimental animal models

Abstract

Context: In the present study, different parts (stem and roots) of Bauhinia tomentosa and Kalanchoe pinnata have been screened for antipyretic and analgesic activity. Materials and Methods: Eddy’s hot plate method and acetic acid‑induced writhing test have been performed to elucidate the mechanism of action of analgesic potential whereas antipyretic potential have been evaluated by the yeast induced hyperthermia model. Results and Conclusions: B. tomentosa root extracts at both the doses (200, 400 mg/kg) and stem extracts at high doses (250, 500 mg/kg) were found to possess statistically significant analgesic as well as antipyretic activity when compared to that of control. K pinnata root and stem extracts at both the doses (200, 400 mg/kg) were found to possess statistically significant analgesic and antipyretic activity when compared with that of control. K. pinnata root extracts were found to possess significantly increases in mean latency time whereas failed to inhibit number of writhings in acetic acid‑induced writhing models suggesting its central nervous system action whereas stem extract significantly inhibited number of writhings in acetic acid‑induced writhing methods whereas fail to increase mean latency time at both doses respectively suggesting its peripheral nervous system action. Present study reveals that B. tomentosa (root and stem) possesses significant antipyretic and analgesic effect suggests that the plant may have therapeutic value in hyperthermia associated with pain. Key words: Antinociceptive, acetic acid‑induced writhings, eddy’s hot plate method, flavonoids, yeast induced hyperthermia model