Comparative Analysis of Antibacterial Properties of Fluorescein Derivatives Over Commercial Antibiotics

Abstract

Aim: The study is about to compare the antibacterial properties of Novel Fluorescein derivatives to those of commercial antibiotics, using docking to see how the ligand, protein, and antibiotic interact molecularly. Materials and Methods: The 3 Dimensional structures of protein and ligands were procured from the PubChem, Drug bank, and PDB databases. The sample size was calculated using G power with pretest power at 80% and alpha value of 0.05. The sample size per group is 10 and total sample size is 30. Docking studies of protein and ligands were performed using Auto dock software. Statistics of the interactions were analyzed using IBM SPSS software. Result: Molecular interactions revealed that Clindamycin shows more affinity towards the protein compared to fluorescein and dicloxacillin. The binding affinity values were compared using SPSS software, it reveals that the statistical insignificance observed between the fluorescein and clindamycin is 0.363 and for fluorescein and dicloxacillin is 0.468 Conclusion: Antibiotic clindamycin appears to be more specific and selectively work against the target protein when compared to the dicloxacillin and fluorescein ligands.