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Abstract
Aim. This study was aimed at searching and investigating new substances among phenylethyl derivatives of 3-hydroxypyridine, which exhibit a high actoprotective activity under the conditions of normoxia and acute hypobaric hypoxia.Materials and methods. New compounds of phenylethyl derivatives of 3-hydroxypyridine under the SC code (n = 23) were investigated in comparison with bemethyl and bromantane. The actoprotective activity of new compounds was assessed in experimental animals using a treadmill running test under the conditions of normoxia and acute hypobaric hypoxia. The studied chemical substances and comparative drugs were administered 1 hour prior to exposure of animals to the test. Statistical processing of the obtained experimental results was performed using Microsoft Excel and Statistica for Windows 6.0 software.Results. Among the studied substances, active compounds exhibiting an actoprotective effect have been distinguished. SC-119 chemical substance was revealed, which exceeds the other studied chemicals and bemethyl and bromantane reference actoprotectors in terms of the range of effective doses and actoprotective activity under the conditions of normoxia and acute hypobaric hypoxia.Conclusion. According to the results of the study, the SC-119 compound seems to be a prospective candidate for further research into highly effective actoprotective drugs.
Highlights
According to the results of the study, the SC-119 compound seems to be a prospective candidate for further research into highly effective actoprotective drugs
На основании анализа полученных результатов экспериментального исследования можно сделать вывод о том, что химическое вещество из группы производных фенилэтилпроизводных 3-оксипиридина под шифром СК-119 по широте эффективных доз и выраженности актопротекторного действия превосходит другие исследованные химические соединения и эталонные актопротекторы бемитил и бромантан
Summary
Для наших исследований в качестве потенциально перспективных химических веществ, обладающих актопротекторным действием в условиях нормоксии и острой гипобарической гипоксии (ОГБГ), были выбраны 23 новых фенилэтилпроизводных 3-оксипиридина под шифром СК. Для оценки влияния химических соединений и эталонных препаратов на физическую работоспособность в обычных условиях использовали тест бега в третбане. Соединения под шифрами СК-117 и СК-169 не оказывали влияния на физическую работоспособность мышей по тесту бега в третбане в обычных условиях.
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