Abstract
The gut microbiome in humans is associated with geography, diet, lifestyles and so on, but its relationship with some isolated populations is not clear. We used the 16sRNA technique to sequence the fecal microbiome in the Chinese isolated Yao population and compared it with the major minority Zhuang and the major ethnic Han populations living in the same rural area. Information about diet frequency and health status and routine serum measurements were collected. The unweighted UniFrac principal coordinates analysis showed significant structural differences in fecal microbiota among the three ethnic groups. Statistically significant differences were observed in the community richness estimator (chaos) and the diversity estimator (Shannon) among the three groups. At the genus level, the fecal samples of the isolated Yao population presented the lowest relative abundance of the Megamonas genus, which was potentially related to the high frequency of bean consumption in the diet. Two enterotypes were identified in the overall fecal microbiota in the three populations. In the isolated Yao population, a higher Bacteroides abundance was observed, but the Prevotella abundance decreased with increased alcohol consumption.
Highlights
The human gut microbiota is closely associated with human health[1]
Because the Han population is the major ethnic group in China, and the Zhuang ethnic group is the major minority in Guangxi, we included fecal samples from Han and Zhuang populations in the mountains in the same area as Tu Yao to minimize the influences of genetic background and the environment
Growing evidence supports the diversity of the gut microbiome composition in different ethnic groups
Summary
The human gut microbiota is closely associated with human health[1]. Understanding its abundance and diversity relative to different host characteristics is of great importance. Because the Han population is the major ethnic group in China, and the Zhuang ethnic group is the major minority in Guangxi, we included fecal samples from Han and Zhuang populations in the mountains in the same area as Tu Yao to minimize the influences of genetic background and the environment. We carried out this comparative analysis in these three ethnic groups to characterize the fecal microbiota in Tu Yao and explore its potential relationship with diet, lifestyle and serum biomarkers and examined the potential enterotypes[12] and their association with host properties
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