Abstract
The pyrimidine-purine and pyrimidine-6-methylpurine cross-interactions were compared by measuring the mutually induced concentration-dependent changes in proton chemical shifts in deuterium oxide at 35°C. The chemical shift vs. concentration profiles were analysed using a competitive dimer model. The equilibrium constants (0.41 ± 0.06 and 0.74 ± 0.05 l mol −1 for the pyrimidine-purine and pyrimidine-6-methylpurine hetero-associations, respectively) and the dimer shifts imply that the methylation of purine significantly influences the stacking interaction between the parent molecules of nucleic acid bases and thus their plane-to-plane association structure.
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